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Non-specific Symptoms 2-week-wait pathway

A new 2-week-wait pathway has been developed for patients who present with non-specific symptoms (NSS).  This NSS pathway should be used for patients with the following non-specific symptoms

  • Appetite loss or early satiety
  • Unexplained deep vein thrombosis
  • Diabetes with weight loss age >60
  • Unexplained fatigue
  • Unexplained fever
  • Unexplained night sweats
  • Unexplained Pallor
  • Unexplained pruritis
  • Unexplained weight loss
  • Clinician gut feeling of cancer


If patients present with these NSS, but a likely site for the cancer is identified, the patient should be referred on the site-specific 2WW pathway.


If a likely site cannot be identified, please arrange the following tests so the results will be available for the NSS pathway team

  • CXR
  • Faecal Immunochemical Test (FIT)
  • FBC, ESR or CRP, Renal with eGFR, LFT, TFT, HbA1c, TTG
  • PSA for men
  • CA-125 for women

These tests can be selected as a “group” on DART, pick “CA Non-specific symptoms” male or female.


The referral form should be available on your clinical system, and should be sent to ulh.rdcnssreferrals@nhs.net


This pathway is only available for patients being referred to ULHT.  NWAFT have a similar pathway (Rapid Diagnostic Service), more information about this is available on the LMC website. CCG is working to develop a similar pathway with NLAG.

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